AitKhaled M, Rakik A, Griffin P, et al. A federally funded Research Triangle Institute study of Drug Abuse Resistance Education found that DAREs core curriculum effect on drug use relative to whatever drug education was offered in the control schools is slight and, except for tobacco use, is not statistically significant. Dosage is 4 mg/kg every 12 hours, maximum dosage is 150 mg every 12 hours. 0% or higher.